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openpharma

7 indexed repositories · View on GitHub

mmrm
Mixed Models for Repeated Measures (MMRM) in R.

R · 161 stars
crmPack
Object-Oriented Implementation of CRM Designs

HTML · 22 stars
graphicalMCP
Graphical Multiple Comparison Procedures

R · 21 stars
rbmi
Reference based multiple imputation R package

R · 21 stars
DoseFinding

R · 14 stars
RobinCar2

R · 14 stars
derrick

R · 2 stars

Beginner friendly Everything

Open All

Interaction effects in ancova Open

To be evaluated

Difficulty 5/5 Over a week Newbie friendliness 35/100

openpharma/rbmi#595 · Opened Sep 18, 2026
Incorrect emmeans for models with visit by 'treatment' interaction but no visit main effect due to formula mismatch Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 45/100

openpharma/mmrm#574 · Opened Sep 16, 2026
Restructure plots for NextBest classes Open

enhancement high priority

Difficulty 5/5 Over a week Newbie friendliness 35/100

openpharma/crmPack#967 · Opened Sep 9, 2026
plot.DRMod fails when dose or resp arguments for fitMod are supplied as expression Open

bug

openpharma/DoseFinding#51 · 1 assignee · Opened Aug 20, 2026
Update to roxygen2 8.1.0 to optimize package load time Open

enhancement

openpharma/rbmi#592 · 1 comment · 1 assignee · Opened Aug 5, 2026
Centralize references in the rbmi documentation Open

enhancement

Difficulty 3/5 1-2 days Newbie friendliness 68/100

openpharma/rbmi#591 · 3 reactions · Opened Aug 5, 2026
Add multiple chains option Open

enhancement high priority

Difficulty 5/5 Over a week Newbie friendliness 30/100

openpharma/crmPack#963 · Opened Jul 30, 2026
robin_surv(): factor label collision silently merges distinct joint strata, corrupting estimates Open

bug

openpharma/RobinCar2#118 · 1 comment · 1 assignee · Opened Jul 29, 2026
Feature request: Add `analyse_mi_data()`. Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 42/100

openpharma/rbmi#589 · 3 comments · Opened Jul 27, 2026
vignette ‘FAQ’ not found Open

bug

Difficulty 2/5 1-3 hours Newbie friendliness 64/100

openpharma/rbmi#588 · Opened Jul 23, 2026
Add option to use original Rubin (1987) degrees-of-freedom pooling Open

enhancement

openpharma/rbmi#587 · 8 comments · 1 reaction · 1 assignee · Opened Jul 21, 2026
[Feature Request]: JSON format output Open

enhancement

openpharma/derrick#19 · 1 assignee · Opened Jul 16, 2026
[Feature Request]: Decimal alignment Open

enhancement

openpharma/derrick#18 · 1 assignee · Opened Jul 16, 2026
Dose combination: consider saturated model Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/crmPack#955 · Opened Jul 11, 2026
Improve JAGS code readability by adding section comments Open

documentation

Difficulty 3/5 1-2 days Newbie friendliness 35/100

openpharma/crmPack#954 · Opened Jul 9, 2026
Negative binomial model: Marginal means ignore the model offset Open

openpharma/RobinCar2#117 · 3 comments · 1 assignee · Opened Jul 8, 2026
Ellipse layout OPTION for plot. Open

enhancement

openpharma/graphicalMCP#96 · 1 assignee · Opened Jun 19, 2026
Causal Bayesian version of rbmi that exploits post-ICE data Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/rbmi#563 · 6 comments · Opened Jun 8, 2026
implement MH method Open

openpharma/RobinCar2#113 · 1 assignee · Opened Jun 2, 2026
Clarification in the documentation about weights specification in mmrm Open

documentation

Difficulty 3/5 1-2 days Newbie friendliness 68/100

openpharma/mmrm#566 · 1 reaction · Opened May 6, 2026
Design doc for extending `rbmi` to other endpoints (count, binary, survival) Open

enhancement

openpharma/rbmi#559 · 4 comments · 3 reactions · 1 assignee · Opened May 4, 2026
Bug: graph_test_closure with parametric test rejects hypothesis with larger p-value and less weight over hypothesis with smaller p-value and more weight Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 48/100

openpharma/graphicalMCP#95 · 1 comment · Opened Apr 30, 2026
Support for `emp_start` to apply to other non-spatial covariance structures Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 45/100

openpharma/mmrm#562 · 2 comments · Opened Apr 17, 2026
TiteCRM vignette minor improvement Open

Difficulty 1/5 Under an hour Newbie friendliness 78/100

openpharma/crmPack#941 · Opened Apr 9, 2026
Implement `knit_print` for subclasses of `Simulations` (including tests) Open

openpharma/crmPack#930 · 1 assignee · Opened Jan 26, 2026
Mocking PRNGs in unit tests Open

discussion

Difficulty 4/5 3-5 days Newbie friendliness 35/100

openpharma/crmPack#918 · 3 comments · Opened Dec 5, 2025
enable snapshot comparisons in tests run on GHA Open

cleanup

Difficulty 3/5 1-2 days Newbie friendliness 38/100

openpharma/crmPack#914 · Opened Nov 30, 2025
Support for constrained longitudinal data analysis (cLDA) parametrization Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#551 · 2 comments · 1 reaction · Opened Nov 24, 2025
`simulate` method for `DesignOrdinal` Open

enhancement

Difficulty 3/5 1-2 days Newbie friendliness 35/100

openpharma/crmPack#890 · 3 comments · Opened Nov 13, 2025
Comparison to SAS’ PROC MIXED Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#538 · 6 comments · Opened Sep 29, 2025
Prototype code that could go into simulations table generation Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 20/100

openpharma/crmPack#878 · 1 comment · Opened Sep 23, 2025
SE for marginal mean Open

Difficulty 4/5 3-5 days Newbie friendliness 38/100

openpharma/RobinCar2#92 · Opened Sep 16, 2025
Further details on formulas implemented in `simulated_data()` Open

enhancement

Difficulty 3/5 1-2 days Newbie friendliness 48/100

openpharma/rbmi#522 · Opened Sep 15, 2025
Vignette + function for ERP sample size calculation Open

Difficulty 5/5 Over a week Newbie friendliness 38/100

openpharma/DoseFinding#42 · Opened Jul 31, 2025
Track contributions to the package in more detail Open

Difficulty 4/5 3-5 days Newbie friendliness 20/100

openpharma/DoseFinding#40 · Opened Jul 23, 2025
Review of `parametric_ci()` Open

bug

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/rbmi#512 · Opened Jul 11, 2025
Better support for imputed dataframe export Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 30/100

openpharma/rbmi#511 · 1 comment · 1 reaction · Opened Jul 11, 2025
Functionality for imputation of single post-baseline Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 38/100

openpharma/rbmi#510 · 4 comments · Opened Jul 2, 2025
Improve tools for creating complete dataset Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 48/100

openpharma/rbmi#509 · 1 reaction · Opened Jun 26, 2025
Make error handling more user friendly Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 35/100

openpharma/rbmi#500 · Opened Jun 10, 2025
Diagonal covariance structure, un-unique intra subject levels Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 30/100

openpharma/mmrm#505 · 5 comments · Opened May 7, 2025
Add closed MCP-Mod functionality Open

Difficulty 5/5 Over a week Newbie friendliness 20/100

openpharma/DoseFinding#32 · Opened May 5, 2025
Update analyse() to support data.frame input Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/rbmi#494 · 8 comments · Opened Apr 16, 2025
Extension using post intercurrent event data to impute missing data for binary endpoints Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/rbmi#492 · 3 comments · Opened Apr 3, 2025
Proposal to support BOIN methodology Open

design enhancement high priority

openpharma/crmPack#872 · 1 comment · 1 reaction · 2 assignees · Opened Mar 13, 2025
Move thinning to occur after fitting the Stan model Open

enhancement good first issue

Difficulty 3/5 1-2 days Newbie friendliness 45/100

openpharma/rbmi#491 · Opened Mar 11, 2025
Clear up parallel processes if processing fails Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 30/100

openpharma/rbmi#488 · Opened Feb 24, 2025
Full test reproducibility appears to be failing on internal tests Open

bug

Difficulty 3/5 1-2 days Newbie friendliness 35/100

openpharma/rbmi#482 · 10 comments · Opened Feb 13, 2025
Support for clustered bootstrap and jackknife - Currently preparing a PR Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/rbmi#471 · 2 comments · Opened Jan 10, 2025
Calculate (approximate) covariance matrix for covariance estimates themselves Open

enhancement SP13

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#493 · Opened Dec 11, 2024

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