openpharma/mmrm

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Mixed Models for Repeated Measures (MMRM) in R.

Stars: 161
Forks: 27
Open beginner issues: 0
Indexed issues: 23

Dominant language: R
License: No license data
Last GitHub push: Jul 2, 2026
Latest indexed: Sep 19, 2026
Contributing guide: Contributing guide
Code of conduct: No code of conduct
Beginner labels: good first issue
PR merge metrics: No merged PRs in 30d

Beginner friendly Everything

Open All

23 open issues indexed

Incorrect emmeans for models with visit by 'treatment' interaction but no visit main effect due to formula mismatch Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 45/100

openpharma/mmrm#574 · Opened Sep 16, 2026
Clarification in the documentation about weights specification in mmrm Open

documentation

Difficulty 3/5 1-2 days Newbie friendliness 68/100

openpharma/mmrm#566 · 1 reaction · Opened May 6, 2026
Support for `emp_start` to apply to other non-spatial covariance structures Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 45/100

openpharma/mmrm#562 · 2 comments · Opened Apr 17, 2026
Support for constrained longitudinal data analysis (cLDA) parametrization Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#551 · 2 comments · 1 reaction · Opened Nov 24, 2025
Comparison to SAS’ PROC MIXED Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#538 · 6 comments · Opened Sep 29, 2025
Diagonal covariance structure, un-unique intra subject levels Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 30/100

openpharma/mmrm#505 · 5 comments · Opened May 7, 2025
Calculate (approximate) covariance matrix for covariance estimates themselves Open

enhancement SP13

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#493 · Opened Dec 11, 2024
Add a spatial covariance structure implementing patient level random effects induced covariance Open

enhancement SP8

Difficulty 5/5 Over a week Newbie friendliness 30/100

openpharma/mmrm#480 · Opened Nov 9, 2024
Add an application vignette Open

documentation good first issue

Difficulty 3/5 1-2 days Newbie friendliness 42/100

openpharma/mmrm#448 · 7 comments · Opened Jun 27, 2024
potentially improve warning/error messages Open

devops SP3

Difficulty 3/5 1-2 days Newbie friendliness 35/100

openpharma/mmrm#393 · 2 comments · 1 reaction · Opened Dec 19, 2023
Once default optimizer fails, try all optimizers but with increased number of iterations Open

enhancement SP3

Difficulty 4/5 3-5 days Newbie friendliness 35/100

openpharma/mmrm#385 · 2 comments · 1 reaction · Opened Dec 13, 2023
Bootstrapping functionality or interface with bootstrap packages Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#372 · Opened Nov 15, 2023
Add `acf` (and maybe vignette with some `plot` examples) Open

enhancement SP5

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#371 · 3 comments · Opened Nov 13, 2023
Cook's distance or DFFIT, DFBETA, leverage Open

enhancement SP5

Difficulty 5/5 Over a week Newbie friendliness 35/100

openpharma/mmrm#368 · 10 comments · Opened Nov 4, 2023
explore the possibility of using sandwich method to obtain the prediction sd Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#345 · 1 comment · Opened Aug 31, 2023
Format simulation results in `simulations/missing-data-benchmarks` Open

openpharma/mmrm#326 · 1 assignee · Opened Aug 2, 2023
SAS Proc Mixed: random element Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#300 · 11 comments · 1 reaction · Opened Jun 22, 2023
Blank out non-observed pairs in estimated covariance matrix display Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 38/100

openpharma/mmrm#279 · Opened Jun 2, 2023
Add Matérn covariance function Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 38/100

openpharma/mmrm#256 · 2 comments · Opened Mar 26, 2023
Raise errors as warnings to avoid capture and re-emission of errors during fit Open

discussion enhancement

Difficulty 3/5 1-2 days Newbie friendliness 45/100

openpharma/mmrm#229 · 1 comment · Opened Jan 24, 2023
use `roxytypes` and `roxylint` packages Open

devops documentation SP5

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#228 · 6 comments · Opened Jan 24, 2023
Consider nested covariance structures? Open

discussion

Difficulty 5/5 Over a week Newbie friendliness 20/100

openpharma/mmrm#174 · 13 comments · Opened Nov 8, 2022
Include `obsweight` functionality Open

discussion

Difficulty 5/5 Over a week Newbie friendliness 25/100

openpharma/mmrm#106 · Opened Sep 6, 2022

openpharma/mmrm

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