OpenCloning/OpenCloning_backend

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The backend application for OpenCloning

Stars: 8
Forks: 11
Open beginner issues: 0
Indexed issues: 43
Avg merge: 14m
Merged PRs (30d): 5

Dominant language: Python
License: MIT
Last GitHub push: Sep 18, 2026
Latest indexed: Sep 19, 2026
Contributing guide: No contributing guide
Code of conduct: No code of conduct
Beginner labels: good first issue

Beginner friendly Everything

Open All

43 open issues indexed

assembly edge case not supported since pydna v5.5.14 Open

Difficulty 3/5 1-2 days Newbie friendliness 52/100

OpenCloning/OpenCloning_backend#497 · Opened Jun 5, 2026
Primer binding functionality to find off-targets Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#456 · Opened May 15, 2026
Test wrong credentials addgene Open

Difficulty 4/5 3-5 days Newbie friendliness 20/100

OpenCloning/OpenCloning_backend#434 · Opened Apr 10, 2026
Clarify assembly topology beyond circular Open

Difficulty 4/5 3-5 days Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#420 · Opened Mar 17, 2026
Refactor homologous_recombination endpoint to allow single inputs for excision, and multiple insertion fragments Open

Difficulty 4/5 3-5 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#368 · 1 comment · Opened Oct 20, 2025
Review blunt handling in known assembly Open

Difficulty 4/5 3-5 days Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#353 · Opened Sep 2, 2025
Handle only_adjacent option for restriction/ligation Open

Difficulty 4/5 3-5 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#352 · Opened Sep 2, 2025
Allowlist error Genbank gives internal server error Open

Difficulty 3/5 1-2 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#340 · Opened Jul 1, 2025
httpclient allowlist error > change to requestError? Open

Difficulty 3/5 1-2 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#339 · Opened Jul 1, 2025
Wrong circular alignment Open

Difficulty 4/5 3-5 days Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#336 · Opened Jun 20, 2025
Should this type of insertion assemble be allowed? Open

question

Difficulty 4/5 3-5 days Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#331 · 2 comments · Opened Jun 17, 2025
Adding Cas12-like Nucleases Open

Difficulty 3/5 1-2 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#328 · Opened Jun 16, 2025
Review format_known_assembly_response Open

Difficulty 3/5 1-2 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#307 · Opened May 26, 2025
Handle NCBI taking too long to respond Open

Difficulty 3/5 1-2 days Newbie friendliness 45/100

OpenCloning/OpenCloning_backend#294 · Opened Apr 22, 2025
Ziqiang et al. template - change one template to 50590? Open

Difficulty 2/5 1-3 hours Newbie friendliness 30/100

OpenCloning/OpenCloning_backend#293 · Opened Apr 14, 2025
Script documentation: mention origin-spanning features Open

Difficulty 2/5 1-3 hours Newbie friendliness 30/100

OpenCloning/OpenCloning_backend#288 · Opened Mar 25, 2025
Migrate assembly code to pydna Open

Difficulty 4/5 3-5 days Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#282 · 1 comment · Opened Mar 17, 2025
Test EBIC primers Open

Difficulty 4/5 3-5 days Newbie friendliness 15/100

OpenCloning/OpenCloning_backend#277 · Opened Feb 27, 2025
Store overhang info in gb file Open

Difficulty 4/5 3-5 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#276 · Opened Feb 24, 2025
permutate_trace: improve discriminating between Sanger and full-plasmid sequence Open

Difficulty 4/5 3-5 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#270 · Opened Feb 19, 2025
Allow cut-through slicing of features Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#260 · Opened Feb 4, 2025
Better error handling for external requests Open

Difficulty 3/5 1-2 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#253 · Opened Dec 17, 2024
Primer design for point mutations Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#233 · Opened Dec 3, 2024
test pLannotate timeout Open

Difficulty 3/5 1-2 days Newbie friendliness 20/100

OpenCloning/OpenCloning_backend#226 · Opened Nov 26, 2024
Support for genome editing Open

OpenCloning/OpenCloning_backend#187 · 4 comments · 1 assignee · Opened Sep 10, 2024
What happens if old AddGene files disappear of if files change Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#184 · 1 comment · Opened Sep 4, 2024
Getting sequence from genome region around a coordinate Open

good first issue

OpenCloning/OpenCloning_backend#178 · 2 comments · 1 assignee · Opened Aug 5, 2024
Handling incorrect information from source Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#176 · 1 comment · Opened Aug 5, 2024
Middleware to rename sequences Open

Difficulty 4/5 3-5 days Newbie friendliness 20/100

OpenCloning/OpenCloning_backend#156 · Opened Jul 9, 2024
Support additional cloning strategies Open

Difficulty 5/5 Over a week Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#151 · Opened Jul 2, 2024
SimpleSequenceLocation -> decide what to do with origin-spanning features Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#141 · Opened Jun 14, 2024
Add template validator Open

Difficulty 5/5 Over a week Newbie friendliness 20/100

OpenCloning/OpenCloning_backend#134 · Opened Jun 7, 2024
Support for recombineering Open

Difficulty 5/5 Over a week Newbie friendliness 15/100

OpenCloning/OpenCloning_backend#132 · Opened May 31, 2024
Optional ids on Sequences and Sources? Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#125 · Opened May 2, 2024
Better handling of uracils Open

Difficulty 4/5 3-5 days Newbie friendliness 25/100

OpenCloning/OpenCloning_backend#80 · 1 comment · Opened Feb 8, 2024
Sequence topology restrictions for assemblies Open

Difficulty 5/5 Over a week Newbie friendliness 20/100

OpenCloning/OpenCloning_backend#68 · Opened Jan 26, 2024
Support for USER cloning Open

next

OpenCloning/OpenCloning_backend#63 · 4 comments · 1 assignee · Opened Jan 16, 2024
Blog post about assemblies Open

Difficulty 5/5 Over a week Newbie friendliness 20/100

OpenCloning/OpenCloning_backend#58 · Opened Dec 23, 2023
Include exceptions in API documentation Open

documentation

Difficulty 5/5 Over a week Newbie friendliness 30/100

OpenCloning/OpenCloning_backend#36 · 1 reaction · Opened Aug 26, 2022
Make a name pattern for output sequences Open

Difficulty 5/5 Over a week Newbie friendliness 20/100

OpenCloning/OpenCloning_backend#21 · 1 comment · Opened May 4, 2022
Keep a list/read-only sqlite database to repell known bot IPs Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 20/100

OpenCloning/OpenCloning_backend#5 · Opened Jan 13, 2022
Switch to uvicorn production mode when serving from the container Open

enhancement

Difficulty 3/5 1-2 days Newbie friendliness 35/100

OpenCloning/OpenCloning_backend#4 · Opened Jan 13, 2022
Add example requests for the API docs Open

documentation good first issue

Difficulty 3/5 1-2 days Newbie friendliness 45/100

OpenCloning/OpenCloning_backend#2 · Opened Jan 13, 2022

OpenCloning/OpenCloning_backend

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