pharmaverse/aNCA

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Shiny App to perform NCA on (pre-)clinical data

Stars: 44
Forks: 17
Open beginner issues: 0
Indexed issues: 194
Avg merge: 3d 15h
Merged PRs (30d): 17

Dominant language: R
License: Apache-2.0
Last GitHub push: Sep 16, 2026
Latest indexed: Sep 19, 2026
Contributing guide: Contributing guide
Code of conduct: Code of conduct
Beginner labels: good first issue help wanted

Beginner friendly Everything

Open All

194 open issues indexed

Enhancement: Add merge-conflict resolution skill Open

enhancement

Difficulty 2/5 1-3 hours Newbie friendliness 86/100

pharmaverse/aNCA#1490 · Opened Sep 16, 2026
Enhancement: add GENDER and SPECIES to grouping variable auto-mapping Open

enhancement

Difficulty 2/5 1-3 hours Newbie friendliness 78/100

pharmaverse/aNCA#1486 · Opened Sep 10, 2026
Bug: Make ratio PPANMETH describe reference and multiplier settings Open

bug

Difficulty 3/5 1-2 days Newbie friendliness 68/100

pharmaverse/aNCA#1484 · Opened Sep 8, 2026
Enhancement: Mark summary-excluded records in TLG listings Open

enhancement TLG

pharmaverse/aNCA#1482 · 1 assignee · Opened Sep 7, 2026
Bug: Parameter Selection matrix silently ignores selections for metabolite/NA study types (METABFL label mismatch) Open

bug

Difficulty 3/5 1-2 days Newbie friendliness 76/100

pharmaverse/aNCA#1471 · Opened Sep 2, 2026
Enhancement: Redesign ADPP Exclusions tab with integrated boxplots and red/yellow/orange exclusion coding Open

enhancement

pharmaverse/aNCA#1466 · 1 assignee · Opened Aug 31, 2026
Enhancement: Custom naming and per-study-type selection for Partial Interval Calculations Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 48/100

pharmaverse/aNCA#1463 · Opened Aug 31, 2026
Enhancement: Offer ROUTE as a "Group by" option in NCA descriptive statistics (and fix ROUTE join crash) Open

bug enhancement

Difficulty 4/5 3-5 days Newbie friendliness 68/100

pharmaverse/aNCA#1461 · Opened Aug 31, 2026
Standardise formulation variable name DOSFRM -> FRMUL in mapping/app Open

enhancement

Difficulty 3/5 1-2 days Newbie friendliness 76/100

pharmaverse/aNCA#1453 · Opened Aug 27, 2026
Enhancement: metadata-driven CDISC data-type validation + QC report on export Open

enhancement

Difficulty 5/5 Over a week Newbie friendliness 48/100

pharmaverse/aNCA#1451 · Opened Aug 27, 2026
Code TODO inventory and cleanup tracking Open

Difficulty 5/5 Over a week Newbie friendliness 25/100

pharmaverse/aNCA#1447 · Opened Aug 26, 2026
Bug: Terminal-slope/half-life parameters report non-imputed values while AUCinf/CL use the imputed slope Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 58/100

pharmaverse/aNCA#1443 · Opened Aug 25, 2026
Bug: Half-life results can be reported from a different imputation context than dependent NCA results Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 45/100

pharmaverse/aNCA#1442 · Opened Aug 25, 2026
Bug: Summary-exclusion flags (PKSUMXF/PPSUMXF) filter individual TLG plots, not only summary tables and mean plots Labels: bug, TLG Open

bug

pharmaverse/aNCA#1438 · 2 assignees · Opened Aug 24, 2026
Bug: Metabolite lambda-z not reported as "Manual" (LAMZMTD) after slope selector changes Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 45/100

pharmaverse/aNCA#1435 · Opened Aug 21, 2026
Robustness: imputed vs non-imputed result rows deduplicated by slice_tail row order instead of selecting by PPANMETH Open

bug

Difficulty 3/5 1-2 days Newbie friendliness 65/100

pharmaverse/aNCA#1434 · Opened Aug 21, 2026
Enhancement: switch TLG sidebar selects to pickerInput Open

enhancement TLG UX

pharmaverse/aNCA#1432 · 1 assignee · Opened Aug 13, 2026
Enhancement: make Displayed variables consistent across TLG listings Open

enhancement TLG

pharmaverse/aNCA#1431 · 1 assignee · Opened Aug 13, 2026
Enhancement: default titles, subtitles and footnotes for the TLG catalog Open

enhancement TLG UX

pharmaverse/aNCA#1430 · 1 assignee · Opened Aug 13, 2026
Bug: metabolite/parent TLG outputs summarize metabolite rows instead of computing M/P ratios Open

bug TLG

pharmaverse/aNCA#1429 · 1 assignee · Opened Aug 13, 2026
Reviewer check: metabolite ratios in TLG outputs Open

enhancement TLG

pharmaverse/aNCA#1427 · 1 assignee · Opened Aug 11, 2026
Bug: verify ATPTREF is included and visible in ADPP outputs Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 48/100

pharmaverse/aNCA#1426 · Opened Aug 11, 2026
Enhancement: Allow ordering slope selector plots by ATPTREF and improve the "Order plots by" UX Open

enhancement

Difficulty 4/5 3-5 days Newbie friendliness 55/100

pharmaverse/aNCA#1421 · Opened Aug 6, 2026
Bug: Running NCA on both Urine and Plasma yields no Urine PK parameters in the results Open

bug

Difficulty 3/5 1-2 days Newbie friendliness 62/100

pharmaverse/aNCA#1422 · Opened Aug 6, 2026
Bug: Slope-related parameter calculation when a slope includes both point selection and point exclusion Open

bug

Difficulty 3/5 1-2 days Newbie friendliness 65/100

pharmaverse/aNCA#1415 · Opened Jul 31, 2026
Enhancement: Drop end-of-interval concentration belonging to the next dose Open

bug

Difficulty 4/5 3-5 days Newbie friendliness 55/100

pharmaverse/aNCA#1414 · Opened Jul 28, 2026
Best practices still missing Open

pharmaverse/aNCA#1405 · 1 assignee · Opened Jul 20, 2026
WISH: follow-up test hardening from PR #1360 review Open

enhancement WISH

Difficulty 3/5 1-2 days Newbie friendliness 74/100

pharmaverse/aNCA#1399 · Opened Jul 16, 2026
Bug: rename PP summary exclusion flags to CDISC-compliant names (PPSUMFL → PPSUMXF) Open

bug good first issue

Difficulty 4/5 3-5 days Newbie friendliness 70/100

pharmaverse/aNCA#1395 · Opened Jul 14, 2026
Bug: rename PK summary exclusion flags to CDISC-compliant names (PKSUM1F → PKSUMXF) Open

bug good first issue

Difficulty 3/5 1-2 days Newbie friendliness 72/100

pharmaverse/aNCA#1394 · 1 comment · Opened Jul 14, 2026
Community thread: bug finders — report anything you spot in the App Open

bug good first issue

Difficulty 5/5 Over a week Newbie friendliness 25/100

pharmaverse/aNCA#1384 · Opened Jul 9, 2026
Community thread: create an App tutorial (your format, open-source friendly) Open

documentation good first issue

Difficulty 3/5 1-2 days Newbie friendliness 65/100

pharmaverse/aNCA#1385 · Opened Jul 9, 2026
Community thread: UI improvement suggestions Open

good first issue UX

Difficulty 5/5 Over a week Newbie friendliness 25/100

pharmaverse/aNCA#1383 · Opened Jul 9, 2026
Docs: expand the FAQ with common user questions Open

documentation good first issue

Difficulty 2/5 1-3 hours Newbie friendliness 52/100

pharmaverse/aNCA#1381 · Opened Jul 9, 2026
Docs: add a PK/NCA parameter glossary to the "What is NCA?" article Open

documentation good first issue

Difficulty 2/5 1-3 hours Newbie friendliness 76/100

pharmaverse/aNCA#1382 · Opened Jul 9, 2026
Accessibility: add accessible name to icon-only help dropdown triggers Open

good first issue UX

Difficulty 4/5 3-5 days Newbie friendliness 48/100

pharmaverse/aNCA#1377 · Opened Jul 7, 2026
Tests: write unit tests for R/utils-plots.R Open

good first issue

pharmaverse/aNCA#1375 · 1 comment · 1 assignee · Opened Jul 7, 2026
Tests: write unit tests for R/run_app.R Open

good first issue

Difficulty 3/5 1-2 days Newbie friendliness 68/100

pharmaverse/aNCA#1376 · Opened Jul 7, 2026
Accessibility: add aria-label to icon-only buttons Open

good first issue UX

Difficulty 3/5 1-2 days Newbie friendliness 88/100

pharmaverse/aNCA#1372 · Opened Jul 7, 2026
UX: standardize trailing punctuation in showNotification messages Open

good first issue UX

Difficulty 2/5 1-3 hours Newbie friendliness 84/100

pharmaverse/aNCA#1366 · Opened Jul 6, 2026
UX: show the max upload size in the file upload UI Open

enhancement good first issue UX

pharmaverse/aNCA#1365 · 1 comment · 1 assignee · Opened Jul 6, 2026
Enhancement: TLG catalog page on aNCA pkgdown site Open

enhancement

pharmaverse/aNCA#1361 · 1 assignee · Opened Jun 30, 2026
🎉 Hackathon Hub — Good First Issues for New Contributors Open

documentation good first issue help wanted

Difficulty 1/5 Under an hour Newbie friendliness 20/100

pharmaverse/aNCA#1357 · Opened Jun 23, 2026
Bug: Auto-restore does not run NCA after uploading settings Open

bug

Difficulty 3/5 1-2 days Newbie friendliness 55/100

pharmaverse/aNCA#1348 · 1 comment · Opened Jun 3, 2026
Enhancement: Add ADPP-based TLG functions (PK parameter tables and graphs) Open

enhancement TLG

pharmaverse/aNCA#1346 · 1 assignee · Opened Jun 2, 2026
Enhancement: TLG order details saved and restored via settings file Open

enhancement TLG

pharmaverse/aNCA#1345 · 1 assignee · Opened Jun 2, 2026
Enhancement: Allow export/download of all generated TLGs Open

enhancement TLG

pharmaverse/aNCA#1344 · 1 assignee · Opened Jun 2, 2026
Enhancement: TLG section improvements — tracking issue Open

enhancement TLG

pharmaverse/aNCA#1337 · 1 comment · 2 assignees · Opened May 28, 2026
Enhancement: Consistent color theme for TLG plots (post-tern/nestcolor removal) Open

enhancement TLG UX

Difficulty 4/5 3-5 days Newbie friendliness 45/100

pharmaverse/aNCA#1324 · Opened May 27, 2026
Enhancement: Filter out time points with >50% BLQ in mean TLG plots Open

enhancement TLG

Difficulty 4/5 3-5 days Newbie friendliness 55/100

pharmaverse/aNCA#1323 · Opened May 27, 2026

pharmaverse/aNCA

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