openpharma / openpharma/crmPack
Add support for "smallest/largest next best" dose
@Puzzled-Face is already working on this.
Since Sep 12, 2024.
- #857 by @Puzzled-Face — closed without merging
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Description
Some trials, most obviously those using ordinal models, may need to recommend a dose based on the minimum/maximum of different NextBest rules.
For example
The dose recommended for the next cohort will be the dose that maximises the probability that the chance of a grade 1 toxicity is in the range [0.2, 0.33] amongst those doses that have a probability of a grade 2 toxicity is less than 0.05.
This is not currently supported, but would be by the creation of NextBestMin (and NextBestMax) classes with behaviour analogous to CohortSizeMin and CohortSizeMax.
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