microsoft/foldingdiff

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Diffusion models of protein structure; trigonometry and attention are all you need!

Stars: 568
Forks: 74
Open beginner issues: 0
Indexed issues: 12
Avg merge: 20h 2m
Merged PRs (30d): 1

Dominant language: Jupyter Notebook
License: MIT
Last GitHub push: Sep 9, 2026
Latest indexed: Sep 19, 2026
Contributing guide: Contributing guide
Code of conduct: Code of conduct
Beginner labels: No beginner labels indexed

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12 issues indexed so far

Error when calculating Maximum training similarity TM scores Open

Difficulty 4/5 3-5 days Newbie friendliness 38/100

microsoft/foldingdiff#32 · Opened Jul 25, 2025
How to use multithreading to speed up KL calculations？ Open

Difficulty 4/5 3-5 days Newbie friendliness 30/100

microsoft/foldingdiff#28 · 1 comment · Opened Sep 24, 2024
Conditional generation Open

Difficulty 5/5 Over a week Newbie friendliness 20/100

microsoft/foldingdiff#26 · Opened Mar 11, 2024
Where is wrapped gaussian sampling done during noising? Open

Difficulty 1/5 Under an hour Newbie friendliness 20/100

microsoft/foldingdiff#25 · Opened Jan 10, 2024
backbone with clashes Open

Difficulty 4/5 3-5 days Newbie friendliness 25/100

microsoft/foldingdiff#24 · Opened Jan 9, 2024
BERT or Transformer? Open

Difficulty 3/5 1-2 days Newbie friendliness 35/100

microsoft/foldingdiff#22 · Opened Jun 16, 2023
Training my own dataset Open

Difficulty 4/5 3-5 days Newbie friendliness 30/100

microsoft/foldingdiff#20 · 1 comment · Opened Apr 9, 2023
Error when I run Sampling protein backbones Open

Difficulty 3/5 1-2 days Newbie friendliness 25/100

microsoft/foldingdiff#19 · 3 comments · Opened Mar 16, 2023
Submit training code error Open

Difficulty 2/5 1-3 hours Newbie friendliness 25/100

microsoft/foldingdiff#18 · 1 comment · Opened Mar 7, 2023
Error when using script partial_noise_reconstruct.py Open

Difficulty 2/5 1-3 hours Newbie friendliness 35/100

microsoft/foldingdiff#17 · 2 comments · Opened Feb 17, 2023
Minimum number of structures to train model Open

Difficulty 4/5 3-5 days Newbie friendliness 20/100

microsoft/foldingdiff#16 · 1 comment · Opened Feb 14, 2023
How to do inpainting? Open

Difficulty 5/5 Over a week Newbie friendliness 20/100

microsoft/foldingdiff#9 · 1 comment · Opened Nov 29, 2022

microsoft/foldingdiff

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