ga4gh/vrs

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Extensible specification for representing and uniquely identifying biological sequence variation

Stars: 98
Forks: 43
Open beginner issues: 0
Indexed issues: 35
Avg merge: 15h 37m
Merged PRs (30d): 6

Dominant language: Jupyter Notebook
License: Apache-2.0
Last GitHub push: Sep 1, 2026
Latest indexed: Sep 16, 2026
Contributing guide: Contributing guide
Code of conduct: No code of conduct
Beginner labels: good first issue

Open All

35 open issues indexed

Write specification for representing translocations and fusions/junctions Open

Requirements Schema Stayin' Alive SV

ga4gh/vrs#28 · 31 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Implement support for transcript-based locations Open

Schema Stayin' Alive

ga4gh/vrs#199 · 10 comments · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Use cases for gene locations. Open

Requirements Schema Stayin' Alive

ga4gh/vrs#263 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Explicit IUPAC tables Open

Docs Stayin' Alive

ga4gh/vrs#269 · 1 comment · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Add functions to test whether or not two variants are "equivalent" Open

nice to have

ga4gh/vrs#336 · 1 comment · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Validated example support Open

Docs nice to have

ga4gh/vrs#349 · 2 comments · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Update validation suite for all classes Open

Good First Issue nice to have

ga4gh/vrs#357 · 2 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Clarify array ordering documentation Open

Docs

ga4gh/vrs#378 · 3 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Inconsistent genotype.count definitions Open

ga4gh/vrs#424 · 1 comment · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Write summary of new features Open

ga4gh/vrs#538 · 2 comments · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Add html build and critical warnings check to PR github action Open

ga4gh/vrs#559 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Add Identifiers to Entity Open

ga4gh/vrs#563 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Appendix discussing Structural Variation Open

Product Review

ga4gh/vrs#572 · 1 comment · 0 reactions · 1 assignee · Indexed Sep 16, 2026
analyze modifications to MSP to draft diagrams Open

Docs

ga4gh/vrs#576 · 1 comment · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Revise introduction to prominently communicate intent of standard Open

Product Review

ga4gh/vrs#578 · 1 comment · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Automate examples in docs Open

ga4gh/vrs#603 · 0 comments · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Contributing docs reference a branch that doesn't exist Open

Bug Docs

ga4gh/vrs#606 · 1 comment · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Add test coverage for VRS trial use models Open

ga4gh/vrs#619 · 3 comments · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Encoding of adjacency directionality through use of `start` and `end` leads to complex queries Open

ga4gh/vrs#627 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Definition of `refgetAccession` diverges from GA4GH RefGet Open

ga4gh/vrs#628 · 0 comments · 1 reaction · 0 assignees · Indexed Sep 16, 2026
Definition of [Systemic Variation](https://vrs.ga4gh.org/en/2.0.0-ballot.2024-11/concepts/SystemicVariation/index.html#systemic-variation) is misleading Open

ga4gh/vrs#629 · 1 comment · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Add contributing section to RTD Open

Docs

ga4gh/vrs#642 · 0 comments · 0 reactions · 1 assignee · Indexed Sep 16, 2026
Explicitly doc inheritance (consistency check) Open

ga4gh/vrs#645 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Resolve Sphinx doc warnings Open

ga4gh/vrs#648 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Add Supported syntax Values to Expression Field Documentation Open

ga4gh/vrs#651 · 1 comment · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Request for URI Support to Preserve Semantics in FHIR Translation Open

ga4gh/vrs#652 · 4 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Relative links in schemas break (some) schema parsers Open

ga4gh/vrs#654 · 1 comment · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Provide implementation guidance on use of Expressions Open

Docs

ga4gh/vrs#658 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Update normalization schema in normalization.rst Open

Docs

ga4gh/vrs#662 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Updates to Quick Start Page Open

Docs

ga4gh/vrs#668 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Write documentation and normalization conventions for RelativeAllele Open

Docs

ga4gh/vrs#669 · 1 comment · 1 reaction · 0 assignees · Indexed Sep 16, 2026
2026 Connect Hackathon: Quick start Open

ga4gh/vrs#690 · 1 comment · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Expand description or include schema in docs for `Range` Open

Docs

ga4gh/vrs#694 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Redesign and remove `Range` polymorphism from `start`/ `end` attributes Open

ga4gh/vrs#706 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026
Verify VRS digest serialization actually matches RFC 8785 (JCS) output byte-for-byte Open

ga4gh/vrs#712 · 0 comments · 0 reactions · 0 assignees · Indexed Sep 16, 2026

ga4gh/vrs

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