CDCgov / CDCgov/DynODE

More consideration on IHR priors?

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experiment question
Dominant language
Python
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Merged PRs (30d)
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Description

Given that this is a big model to compute (as in a lot of compartments), and we want to do Bayesian analysis, then its probably a good idea to make strong priors where possible.

I think the priors for infection-hospitalisation-ratio (IHR) are too vague and should probably reflect known age structure in IHR?

https://github.com/cdcent/cfa-scenarios-model/blob/dfbd4ded9fddf2dafcd793f73f751e6067ccd9f2/mechanistic_model/mechanistic_inferer.py#L130-L131

The prior range here looks like prior mean 4.8% IHR with 2.5-97.5% range: 0.005% - 22.7% with no age variation.

For me thats too vague and doesn't help the sampler (or indeed the reasoning); I think we can tighten those priors and add age structure.

NB: Pre-apologies if I'm not getting something here!

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Research direction

Start by reviewing mechanistic_model/mechanistic_inferer.py around lines 130–131 and the surrounding Bayesian inference setup. Determine how the current IHR prior is represented and what age-structured information is available in the model. Done means proposing and implementing tighter, age-varying IHR priors with evidence that the resulting assumptions better support sampling and interpretation.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
backend
Issue type
Feature
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Mostly clear
Newbie friendliness
30/100

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