Python installation fails to install pip3 if pip, setuptools in ~/.local

GitHub fields:

assignee = None
closed_at = None
created_at = <Date 2021-02-01.15:51:40.516>
labels = ['expert-installation', '3.10']
title = 'Python installation fails to install pip3 if pip, setuptools in ~/.local'
updated_at = <Date 2021-02-01.15:51:40.516>
user = 'https://bugs.python.org/quotemstr'

bugs.python.org fields:

activity = <Date 2021-02-01.15:51:40.516>
actor = 'quotemstr'
assignee = 'none'
closed = False
closed_date = None
closer = None
components = ['Installation']
creation = <Date 2021-02-01.15:51:40.516>
creator = 'quotemstr'
dependencies = []
files = []
hgrepos = []
issue_num = 43092
keywords = []
message_count = 1.0
messages = ['386079']
nosy_count = 1.0
nosy_names = ['quotemstr']
pr_nums = []
priority = 'normal'
resolution = None
stage = None
status = 'open'
superseder = None
type = None
url = 'https://bugs.python.org/issue43092'
versions = ['Python 3.10']