openvax / openvax/varcode

Switch to interbase coordinates

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#40 2 comments 0 reactions 0 assignees View on GitHub

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Dominant language
Python
Stars
87
Forks
28
Avg merge
3h 27m
Merged PRs (30d)
27

Description

Currently have a lot of special case logic for insertions (e.g. if len(ref) == 0), can use unified logic if the start/end coordinates are between bases.

See: http://alternateallele.blogspot.de/2012/03/genome-coordinate-conventions.html

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by locating the insertion handling and the start/end coordinate logic in the Python code, then read the linked genome coordinate conventions article. Done means insertions use unified coordinates between bases without special cases such as if len(ref) == 0; the issue names no specific files or tests.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
bioinformatics
Issue type
Refactor
Difficulty
4/5
Estimated time
3-5 days
Activity status
Stale
Clarity
Mostly clear
Newbie friendliness
35/100

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