nf-core / nf-core/pairgenomealign

Add a `--circular` option

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enhancement
Dominant language
Nextflow
Stars
12
Forks
5
Avg merge
1d 10h
Merged PRs (30d)
6

Description

Description of feature

The new LAST version has a --circular option. It is useful for searching for Nuclear mitochondrial DNA segment (NUMTs) in nuclear genomes. It would be cool to support it.

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by locating where the pairgenomealign workflow assembles and runs LAST commands, then trace how command-line options are exposed. The change is complete when the pipeline accepts a circular-search option and passes it through to LAST for NUMT searches; verify the relevant workflow execution with a suitable example.

Written by the indexing model from the issue text.

Assessment

Domain
bioinformatics
Issue type
Feature
Difficulty
3/5
Estimated time
1-2 days
Activity status
Stale
Clarity
Mostly clear
Newbie friendliness
45/100

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