nf-core / nf-core/methylarray

[Extras] Investigate possibility of inferring sex of samples and comparing them with sex from the pheno sheet

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enhancement
Dominant language
Nextflow
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9
Forks
6
PR merge metrics
No merged PRs in 30d

Description

Description of feature

Sex of human samples can be inferred from the methylation data and compared with the provided real sex to compare and check of outliers or detect possible samples swaps.

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

No files, tests, entry points, or implementation approach are named. Start by reviewing how methylation data and the pheno sheet enter the pipeline, then identify whether an existing workflow step supports sex inference. Done should include a defined comparison and a documented way to report mismatches or possible sample swaps.

Written by the indexing model from the issue text.

Assessment

Domain
bioinformatics
Issue type
Feature
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
25/100

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