fulcrumgenomics / fulcrumgenomics/ref-solver
feat: support MD5 lookup for common FASTA mutations (repeat-masked, soft-masked)
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- Dominant language
- Rust
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- 33
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Description
When a user provides an MD5 that doesn't match any catalog entry (e.g. `3a7b8f4c8f5a975a9e656ea77bfa1498` for chr1), it may be from a modified reference (repeat-masked, soft-masked via sdust, etc.) rather than an error.
We could pre-compute and catalog MD5s for common FASTA mutations:
- RepeatMasker (hard-masked)
- sdust / DUST (soft-masked)
- Other common transformations (e.g. lowercase conversion)
This would allow ref-solver to identify modified references and report what transformation was likely applied.
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