Binder design - clarification on number of binders per target

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Assessment

Difficulty
4/5
Estimated time
3-5 days
Newbie friendliness
20/100
Issue type
Documentation
Clarity
Needs clarification
Activity status
Stale
Domain
documentation

Research direction

Start with the README's Binder design scale section and the paper passages cited in the issue. Compare how binder generation, filtering, and experimental testing are described, then confirm the interpretation with the project’s documented workflow. Done means the README or linked documentation clearly reconciles the reported counts.

Written by the indexing model from the issue text.

Description

Hi,

I have a question regarding the binder generation and testing process mentioned in the README and the paper.

In the README, it is stated that approximately 10,000 binder backbones were generated for each target. However, in the paper, it is mentioned that "Binders were identified for all 4 targets, with fewer than 100 designs tested per target compared to thousands in previous studies."

Could you please clarify if this means that 10,000 binders were initially generated and then filtered down to 100, which were subsequently tested experimentally in the lab?

Thank you for your time and clarification!

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Python
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