DNS Cache question

Under "Advanced settings" there is "DNS Cache" option.

Can you please explain, is this cache a separate DNS cache that is maintained by dnscrypt-proxy, or is this DNS cache belonging to Windows OS?

I ask this because I want to clear the cache, if it's cache by OS, then simply `Clear-DNSClientCache` in PowerShell will do, however if it's cache maintained by dnscrypt-proxy, then how do you clear it?