AlexsLemonade / AlexsLemonade/refinebio

Recover samples w/ mismatched salmon versions / transcriptome indices

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#2,006 21 comments 0 reactions 1 assignee Claimed by @arielsvn View on GitHub
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Python
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Description

### Context

@arielsvn was looking into a user request in issue https://github.com/AlexsLemonade/refinebio/issues/1996#issuecomment-566190000 .

### Problem or idea

In at least some cases, we had at least one `quant.sf` file already processed for a sample. When we upgraded salmon's transcriptome indices we ended up with `quant.sf` files that cannot be merged.

### Solution or next step

We should query for any cases where have samples from the same experiment processed with different transcriptome indices. We should reprocess all of these with the latest version and attempt to run tximport over samples processed with the latest version.

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