sokrypton / sokrypton/ColabFold

Error with RosettaFold2 Setup

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Description

When running RosettaFold2 setup I get next error:

UnpicklingError Traceback (most recent call last)
in

/content/RoseTTAFold2/network/predict.py in
6 from torch.utils import data
7 from parsers import parse_a3m, read_templates, read_template_pdb, parse_pdb
----> 8 from RoseTTAFoldModel import RoseTTAFoldModule
9 import util
10 from collections import namedtuple

9 frames
/usr/local/lib/python3.11/dist-packages/torch/serialization.py in load(f, map_location, pickle_module, weights_only, mmap, **pickle_load_args)
1468 )
1469 except pickle.UnpicklingError as e:
-> 1470 raise pickle.UnpicklingError(_get_wo_message(str(e))) from None
1471 return _load(
1472 opened_zipfile,

UnpicklingError: Weights only load failed. This file can still be loaded, to do so you have two options, do those steps only if you trust the source of the checkpoint.
(1) In PyTorch 2.6, we changed the default value of the weights_only argument in torch.load from False to True. Re-running torch.load with weights_only set to False will likely succeed, but it can result in arbitrary code execution. Do it only if you got the file from a trusted source.
(2) Alternatively, to load with weights_only=True please check the recommended steps in the following error message.
WeightsUnpickler error: Unsupported global: GLOBAL builtins.slice was not an allowed global by default. Please use torch.serialization.add_safe_globals([slice]) or the torch.serialization.safe_globals([slice]) context manager to allowlist this global if you trust this class/function.

Check the documentation of torch.load to learn more about types accepted by default with weights_only https://pytorch.org/docs/stable/generated/torch.load.html.

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Research direction

Start with network/predict.py and the RoseTTAFoldModel import shown in the traceback, then review the torch.load failure and the linked PyTorch serialization guidance. Reproduce the setup with the reported Python 3.11 and PyTorch 2.6 environment, checking the checkpoint source before changing loading behavior. Done means the RosettaFold2 setup completes without this UnpicklingError.

Written by the indexing model from the issue text.

Assessment

Tech stack
jupyter, python, pytorch
Domain
bioinformatics, machine-learning
Issue type
Bug
Difficulty
3/5
Estimated time
1-2 days
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
35/100

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