sokrypton / sokrypton/ColabFold
prediction error using alphafold multimer
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Description
Hi,
I'm designing antibody for my protein using RFdiffusion and ProteinMPNN.
subsequently, I'm predicting the structure of the sequence obtained from proteinMPNN using colabfold alphafold multimer.
I have a question about the structure obtained from colabfold alphafold multimer.
first, my protein is dimer. so, I predict that, designed antibody interacts only one protomer of dimer.
however, designed antibody seems to combine (interact) center of the dimer.
I think the antibody is slightly shifted.
Is there any solution?
What can I try?
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Research direction
Review the reported RFdiffusion → ProteinMPNN → ColabFold AlphaFold Multimer workflow and reproduce the dimer/antibody prediction described in the issue. A useful resolution would identify whether the central binding geometry is expected or a reproducible prediction problem and document a concrete setting or workflow to try; the issue provides no sequence, notebook, or test.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- jupyter-notebook
- Domain
- bioinformatics
- Issue type
- Bug
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 15/100