sokrypton / sokrypton/ColabFold
Mapping protein binding to a known complex
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Description
Hello,
I'm somewhat new to both github and alphafold so my apologies if there's a better place/way to ask my question.
I'm currently studying a protein that is predicted to bind to ribsomes and I'm wondering if there's a way to use ColabFold to predict the structure of the complex of this protein with the existing solved structure of the ribosome. The ribosome contains many different protein subunits as well as a significant amount of rRNA, so it seems overly computationally complex (and redundant since the structure is solved) to input each subunit protein individually when I just want to predict how my protein may dock onto the known pdb structure.
Any advice is much appreciated,
Pierce Ford
Contributor guide
First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
No file, test, or entry point is identified. First determine whether ColabFold has an existing workflow for docking a query protein to a solved ribosome structure, and define completion as documented guidance or a scoped implementation path.
Written by the indexing model from the issue text.
Assessment
- Domain
- bioinformatics
- Issue type
- Feature
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 15/100