sokrypton / sokrypton/ColabFold
Does multimer prediction takes into account experimental structure published after training?
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Description
I am trying to get some predictions of protein-protein complexes.
As "positive" control, I use prediction for a complex for which the cryoEM structure was solved and published in second half of 2022.
When I use colab fold multimer (from ChimeraX software), does the prediction of the structure is using somehow the published structure or is it only relying on the model trained (that does not contain the published structure because it came out after alpha fold multimer)?
Contributor guide
First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
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Research direction
Start by reviewing the ColabFold multimer workflow and its ChimeraX integration, then determine whether predictions can use structures published after model training. Done would be a documented answer explaining whether the 2022 cryoEM structure can influence the prediction.
Written by the indexing model from the issue text.
Assessment
- Domain
- bioinformatics, machine-learning
- Issue type
- Documentation
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 20/100