sokrypton / sokrypton/ColabFold
Calculate ipTM only for actual interacting interfaces?
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- Dominant language
- Jupyter Notebook
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Description
Hi,
would it be possible to add the option to calculate ipTM scores only for the actual interacting interfaces? This would be useful for complexes that have long disordered regions, that lowers the ipTM, although the interface is really good. I tried to calculate it from the output, but realized that I would need the logit probabilities, etc to do that. Can this be implemented (or the necessary outputs returned)?
Contributor guide
First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
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Research direction
No file, test, or entry point is named in the issue. Start by locating the ipTM calculation and the existing result outputs, then determine whether interface selection or the necessary logit probabilities can be exposed. Done means an option or returned data supports calculating ipTM for actual interacting interfaces without relying on disordered regions.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- jupyter-notebook
- Domain
- bioinformatics
- Issue type
- Feature
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 30/100