scverse / scverse/spatialdata-io
Missing tiles in Xenium H&E image
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- Dominant language
- Python
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- 103
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Description
I ran xenium() with default parameters on official data from 10x Genomics (such as https://www.10xgenomics.com/datasets/ffpe-human-breast-with-custom-add-on-panel-1-standard).
However, I noticed that when I plotted the H&E image using the spatialdata-plot package, there were some missing tiles, as shown in the following image:
The missing tiles are always the same if I run xenium() multiple times, so it doesn't look like a random drop.
I checked the original .ome.tif image in QuPath and there are no missing tiles.
Packages version:
spatialdata = 0.2.5spatialdata-io = 0.1.5spatialdata-plot = 0.2.7
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Research direction
Reproduce the issue by running xenium() with default parameters on the linked 10x Genomics dataset, then plot its H&E image with spatialdata-plot. Compare the result with the original .ome.tif in QuPath and investigate why the same tiles are missing; done means the plotted image contains all source tiles.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- data
- Issue type
- Bug
- Difficulty
- 4/5
- Estimated time
- 3-5 days
- Activity status
- Stale
- Clarity
- Mostly clear
- Newbie friendliness
- 35/100