scverse / scverse/scirpy

Clonotype dotplot

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Description

In GitLab by @grst on Mar 31, 2020, 16:56

Scanpy has the dotplot with dendrogram for genes, which I find pretty cool. I would imagine it a good chance to get some overview on the whole dataset to show samples, top clonotype, the size of those clonotypes and either the expansion or the publicness/privateness of that clonotype (later, when we have a nice measure for that)

image

So this could either be:

  • the n-top clonotypes of each sample (which would also give us information about how private/public a clonotype is (if it is expanded in multiple samples). However, in most cases they are at least not shared between patients and the plot would look quite sparse.
  • The size of the top n clonotypes for each sample (on the x axis would be no specific clonotypes, just the rank). This would give us similar information as the clonal expansion plot

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Research direction

Start by reviewing the Scanpy dotplot with dendrogram referenced in the issue and compare the two proposed views: top clonotypes per sample or ranked clonotype sizes. The issue does not name files, tests, an entry point, or a settled definition of done; clarify the visualization design and expected clonotype measures before implementation.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
bioinformatics, data-visualization
Issue type
Feature
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
25/100

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