scverse / scverse/scanpy

Allow plotting heatmap with smoothed expressions per cluster

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Python
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Description

When dealing with many cells, it can be hard to see expression patterns without smoothing. using the PAGA smoothed version doesn’t respect cluster border, however.

It should be possible to specify a smoothing parameter to sc.pl.heatmap.

cc @sophietr

Contributor guide

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First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start at the sc.pl.heatmap entry point and trace how the PAGA-smoothed expression is used for plotting. Add a smoothing parameter that preserves cluster borders, then verify that heatmaps for many cells show the intended smoothed patterns without losing cluster separation.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
data-visualization
Issue type
Feature
Difficulty
4/5
Estimated time
3-5 days
Activity status
Stale
Clarity
Mostly clear
Newbie friendliness
35/100

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