gex_only=True defaults in sc.read_10x_h5
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Description
This might be a bit of a rant, and I'm aware there are some good arguments for the way things are... but I just wasted 4 hours of my life because I wasn't aware of the default gex_only=True in sc.read_10x_h5().
Just wanted to flag that if scanpy support for multimodality becomes a thing, then this default may need to change to prevent frustration. I think moving read/write functionality to AnnData was already discussed at some point. For multimodal support, this might become more important again. If this is moved, then read_10x_h5 should probably not default to gex_only=True anymore.
Would it already be worth either making gex_only a required input? For backward compatability it could also just trigger a logging warning for now. I do think that this is quite an important thing to let people know with more and more 10X Multiome data being generated now (and CITE-seq for that matter).
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First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
Start at the sc.read_10x_h5() entry point and inspect how the gex_only=True default affects 10X multimodal data. Review the proposed relationship between read/write functionality and AnnData, then determine a backward-compatible behavior or warning. Done means the chosen behavior is implemented and clearly communicates how multimodal inputs are handled.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- bioinformatics
- Issue type
- Feature
- Difficulty
- 4/5
- Estimated time
- 3-5 days
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 32/100