scverse / scverse/SnapATAC2

Read bam with split reads

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#259 5 comments 0 reactions 0 assignees View on GitHub

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enhancement :sparkles:
Dominant language
Python
Stars
323
Forks
43
PR merge metrics
No merged PRs in 30d

Description

Hi, first of all thanks a lot for this great tool!

I was wondering if it would be possible to have the make fragment files function from bam files also consider split reads in addition to clipped reads? Do you think this would be difficult to implement?

Thanks a lot for your help!

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First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Locate the function that creates fragment files from BAM files and inspect how it currently handles clipped reads. Determine how split reads should be recognized and included alongside them. Done means fragment files produced from BAM input include the requested split reads, with behavior checked against the existing clipped-read handling.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
data
Issue type
Feature
Difficulty
4/5
Estimated time
3-5 days
Activity status
Stale
Clarity
Mostly clear
Newbie friendliness
35/100

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