scverse / scverse/PyDESeq2

About multifactor analysis

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Description

Is your feature request related to a problem? Please describe.
Do know if this works for factors/conditions that with a continuous number like a signature score

Describe the solution you'd like
when doing this, can the condition only be catigorical? is numerical allowed?
dds = DeseqDataSet(
counts=exp_sel,
metadata=dt_info,
design="~group+condition",
refit_cooks=True,
n_cpus=8
)

Thanks.
hfl

Contributor guide

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First steps

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  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by reading the DeseqDataSet API and the design-formula documentation to determine whether continuous metadata are supported alongside categorical factors. Check any existing examples or tests for designs such as “~group+condition”; done means the supported behavior and required validation or documentation change are clearly established.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
bioinformatics
Issue type
Feature
Difficulty
4/5
Estimated time
3-5 days
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
30/100

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