obophenotype / obophenotype/uberon
Cleanly separate respiratory system epithelia
Nobody has claimed this yet.
- Dominant language
- Emacs Lisp
- Stars
- 163
- Forks
- 43
- Avg merge
- 1d 17h
- Merged PRs (30d)
- 5
Description
Aim: Edit respiratory system epithelia partonomy to have separate terms for:
- alveolar epithelium (AT1, AT2)
- terminal/respiratory bronchiole epithelium (Includes AT0, RAS)
- conducting airway epithelium- (goblet, tuft, multiciliated, neuroendocrine, club) <--- some questions over what to call this.
- respiratory tract gland epithelium (serous/mucous secretory cells and duct cells)
- airway hillock (hillock cells, squamous)
The current partonomy is very tangled. Everything is under respiratory tract epithelium.
This is a problem for CL - it is very hard to separate out cell types cleanly if using inference on location to classify. However, it should be possible to separate these out.
Contributor guide
First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
Start by reviewing the current respiratory tract epithelium partonomy and the five proposed groupings in this issue. Resolve the naming question for conducting airway epithelium and verify that the revised hierarchy cleanly separates the listed epithelial cell types for CL inference; done means the respiratory system epithelia terms and relationships are no longer tangled.
Written by the indexing model from the issue text.
Assessment
- Domain
- data
- Issue type
- Feature
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 25/100