obophenotype / obophenotype/uberon

Airway hillock

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lung new term request Stale
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Description

Preferred term label:

airway hillock

Synonyms

Definition (free text, please give PubMed ID)

A region of squamous epithelium found in the tracheobronchial tree - continuous with the tracheobronchial epithelium -

https://www.nature.com/articles/s41586-024-07377-1

Parent term (use https://www.ebi.ac.uk/ols/ontologies/uberon)

squamous epithelium

part_of tracheobronchial tree

has_part some respiratory hillock cell

Your nano-attribution (ORCID)

** NOTES **

  • THis paper emphasises that hillocks consist of both barrier cells on the surface and a stem cell population that they protect, but we only have a single type of hillock cell in CL.

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by reading the cited Nature paper and checking the proposed parent term and relationships in the Uberon OLS. Add the airway hillock term with a PubMed-backed definition, its parent and stated relations, and resolve whether the cell-ontology note requires more than one hillock cell type.

Written by the indexing model from the issue text.

Assessment

Domain
data
Issue type
Feature
Difficulty
3/5
Estimated time
1-2 days
Activity status
Stale
Clarity
Mostly clear
Newbie friendliness
35/100

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