obophenotype / obophenotype/uberon

The Human placenta in Uberon

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#2,836 4 comments 0 reactions 1 assignee View on GitHub

@aleixpuigb is already working on this.

Since Mar 14, 2023.

HuBMAP Stale uberon-classhierarchy
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Description

The current representation of placenta in Uberon, does not reflect the human anatomy. The following edits have been proposed/requested to make the placenta Human aligned. The major points are:

  • Placental arteries: Add new vascular terms under placental artery UBERON:8480007 and placental vein UBERON:8480008
    image

    • Villous capillary as a child term of placenta blood vessel, instead of placental artery.
  • Placental membrane: The term “placental membrane” in Uberon is not used in the way it is typically used in clinical pathology and obstetrics.

    • Proposal to utilize “placental membrane” in the “structural”/histopathologic term. Then “fetal membrane” should stay where it is (“fetal membrane” should still be made a synonym).
  • Amnion and chorion: “Amnion” and “Chorion” are not related to the “fetal membrane” or “placental membrane”

    • It appears that amnion is being used for an earlier developmental stage (prior to development of the placenta proper). In this case, should introduce a new term: “amniotic membrane”
    • It appears that chorion membrane is being used as a more general term. In this case, would suggest:
      • Change “chorion membrane” to “chorion”
      • Introduce a new term: “chorionic membrane”
        image
  • Chorionic plate: We propose to move “chorionic plate” to be directly a “part-of” the placenta, and organize chorionic villus under it. The terms primary, secondary, and tertiary villus are used in a developmental sense. For the established placenta, would be better to use the terms primary, secondary, and tertiary stem villus.
    image

@emquardokus, do you think that addressing these four points would create a more human representation of the placenta?

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