obophenotype / obophenotype/uberon

blood-brain barrier suggested revisions

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Description

Right now the blood-brain barrier has no relationship to the vascular system in UBERON:
Screenshot 2020-03-25 at 18 54 38

The suggested revisions are based on a recent blood-brain barrier review from the Zlokovic lab: PMID:30280653:

  • Should the ‘neurovascular unit’ be a synonym of the ‘neurovascular bundle’ (UBERON_0016630)?
    [see Figure 1 in a recent review from the Zlokovic lab: https://www.ncbi.nlm.nih.gov/pubmed/30280653];
  • Should the ‘blood-brain barrier’ be a part_of child of ‘neurovascular bundle’ (UBERON_0016630)?
    [see Figure 1 in a recent review from the Zlokovic lab: https://www.ncbi.nlm.nih.gov/pubmed/30280653];
  • Should the ‘blood brain barrier’ also have a relationship to either the vascular plexus (UBERON_0005629), or vasculature (UBERON_0002049)?
    [see section II. A. ‘BBB formation’ in a recent review from the Zlokovic lab: https://www.ncbi.nlm.nih.gov/pubmed/30280653].

cc @RLovering

Contributor guide

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First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Review the definitions and existing relationships for UBERON_0016630, UBERON_0005629, and UBERON_0002049, then compare the proposed modeling to Figure 1 and section II.A of PMID:30280653. Done means reaching a decision on the synonym and vascular relationships and recording the agreed ontology updates.

Written by the indexing model from the issue text.

Assessment

Domain
content
Issue type
Feature
Difficulty
4/5
Estimated time
3-5 days
Activity status
Stale
Clarity
Mostly clear
Newbie friendliness
25/100

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