Roles doing stuff where entities should be?

It seems odd to have roles rather than entities inhibiting, activating etc.

e.g. '4-aminobutyrate transaminase inhibitor' (a CHEBI ROLE) EquivalentTO 'biological role'
and (inhibitor_of some '4-aminobutyrate transaminase activity')

This could work:

'chemical entity' that has_role some 4-aminobutyrate transaminase inhibitor' EquivalentTo inhibitor_of some '4-aminobutyrate transaminase activity'

But perhaps harder to maintain, in which case GO(CHE) style bridging classes might be a good idea.

Alternatively, in the spirit of the BFO conception of this, we might say

4-aminobutyrate transaminase inhibitor (role) EquivalentTo: realised_by some* (inhibition_of some 4-aminobutyrate transaminase activity')

(*only ??? - I don't think this is necessary if roles can be bourne without being realised)

Or combining with a typical GO way of doing things:

4-aminobutyrate transaminase inhibitor (role) EquivalentTo: realised_by some 'negative regulation of 4-aminobutyrate transaminase activity')

Perhaps some use case queries would help clarify the preferred approach.

No files, tests, or entry points are identified in the issue. First resolve the preferred modeling approach using the proposed CHEBI, GO, and BFO alternatives and use-case queries; the work is complete only when that approach is agreed and implemented consistently.