nf-core / nf-core/rnavar

Add minimap2

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enhancement
Dominant language
Nextflow
Stars
61
Forks
47
Avg merge
1d 1h
Merged PRs (30d)
1

Description

Description of feature

From @lindenb

Hi All, FYI, in his latest post, Heng Li suggests that minimap2 could be is better at calling variants.

https://lh3.github.io/2025/04/18/short-rna-seq-read-alignment-with-minimap2

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by reviewing the rnavar pipeline and the minimap2 article linked in the issue. The issue names no files, tests, entry points, or acceptance criteria, so first clarify which workflow stage should use minimap2 and what successful integration and validation would look like.

Written by the indexing model from the issue text.

Assessment

Domain
bioinformatics
Issue type
Feature
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
25/100

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