SIFT missense predictions for genomes
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enhancement
- Dominant language
- Nextflow
- Stars
- 61
- Forks
- 47
- Avg merge
- 1d 1h
- Merged PRs (30d)
- 1
Description
Description of feature
Dear nf-core/rnavar authors,
It would be an amazing feature to include sorting intolerant from tolerant algorithm in the pipeline and rank which one of the variants has the potential to be studied further in details.
Kindly find the nature protocols below:
https://doi.org/10.1038/nprot.2009.86
https://doi.org/10.1038/nprot.2015.123
Contributor guide
First steps
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Research direction
Review the nf-core/rnavar pipeline structure and the two linked SIFT protocol papers first. Determine how variant annotations and ranking are currently represented. Done means the pipeline includes SIFT missense predictions and ranks variants for further study, with the relevant workflow validation completed.
Written by the indexing model from the issue text.
Assessment
- Domain
- bioinformatics
- Issue type
- Feature
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 25/100