Can't load external DLLs from MSIX packed application

What works in normal desktop application

When we try to load a dll from a normal desktop application the system automatically checks the directories specified in the environment variable "PATH" and finally, the dll is found. E.g. we are using NVidia CUDA dlls this way.

What doesn't work when application is packed into MSIX?

When we pack this application into MSIX the dlls can't be found any more, because the packed application doesn't check the folders specified in the environment variable "PATH".

In some cases a workaround would be to load the dll dynamically from code, but it only works when the dll has no dependencies. Otherwise the loaded dll is not able to find it's dependecies.

What's the recommended approach to load the dlls to which path is defined in environment variable "path"?

Start by reproducing the difference between a normal desktop application and an MSIX-packed application when loading NVIDIA CUDA DLLs through PATH. Compare the behavior of dynamic loading and dependency resolution, then document or implement the supported approach for resolving external DLLs and their dependencies in the packaged application.