llrs / llrs/BioCor

How to quantify evidence of co-functionality?

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enhancement question
Dominant language
R
Stars
14
Forks
1
PR merge metrics
No merged PRs in 30d

Description

From [Bioinformatics](https://bioinformatics.stackexchange.com/q/7051/48):

"quantify how likely two genes are correlated in their enrichment, function etc. For example, using STRING we can see that PIK3CA and PTEN are more co-functioning than PIK3CA and SF3B1. "
![8lpz1](https://user-images.githubusercontent.com/6818218/52944607-1862e980-3370-11e9-9338-d80791425aae.png)

The question is how to add this higher co-functioning evidence in BioCor? My answer is that this should be two separate metrics.

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

No file, test, or entry point is named. Start by defining the two separate co-functionality metrics proposed in the issue and determining how they should fit BioCor's existing functional-similarity calculations. Done means the metric definitions and implementation scope are agreed.

Written by the indexing model from the issue text.

Assessment

Tech stack
r
Domain
bioinformatics
Issue type
Feature
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
25/100

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