griffithlab / griffithlab/pVACtools
Calculate HLA-I evolutionary divergence (HED) score
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- Dominant language
- Python
- Stars
- 188
- Forks
- 81
- Avg merge
- 9d 17h
- Merged PRs (30d)
- 6
Description
Given a set of HLA alleles calculate how much HLA diversity is represented using the HLA-I evolutionary divergence (HED) score (Chowell et al., 2019).
Contributor guide
No contributing guide indexed for this repository
First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
Start by locating the code that parses HLA alleles and any existing diversity or scoring entry points. Read the HED method from Chowell et al. (2019), then define the accepted allele inputs, output, and validation needed for a score implementation; the issue provides no file or test location.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- bioinformatics
- Issue type
- Feature
- Difficulty
- 4/5
- Estimated time
- 3-5 days
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 28/100