Generating multiple (>10) models from one sequence

Hi all

I'm new to the field. I would like to generate between 100 and 50 models for my target sequence to explore conformal flexibility of a specific region. This region is often (comparing prediction on my target and various orthologs) predicted with lower confidence, and sometimes with different conformation. We have experimental evidence that this domain may be mobile.

Thus I want to generate many models from the same target sequence to identify possible conformational diversity.

We can run Alphafold locally but I'm not sure how to paramtyrize such a run.

Can anybody help here ?

Thank a bunch
Cedric

—
Prof. Cedric Govaerts, Ph.D.
Universite Libre de Bruxelles
Campus Plaine. Phone :+32 2 650 53 77
Building BC, Room 1C4 203
Boulevard du Triomphe, Acces 2
1050 Brussels
Belgium