google-deepmind / google-deepmind/alphafold

Modeling with a defined template

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feature request usage question
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Description

Hello,

I am modeling a multimer composed of a monomer that binds to a homodimer. The monomer in solution adopts a conformation but when bound to the dimer, it suffers a big conformational change. My goal is to model the monomer in that conformation bound to the dimer.

There are structures of the monomer in solution and a homolog that is in the conformation that I am interested in. Is it possible to define a particular template with a conformation of interest to model a particular chain of a multimer? Or, is it possible to exclude templates for the prediction?

Thanks in advance for the help

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