Whole Cell Modeling

Whole cell models are a very promising avenue of work in systems biology. Can whole cells models be adapted to work in drug discovery contexts?

Relevant papers:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413483/
- http://www.wholecell.org/
- https://github.com/CovertLab/WholeCell
- http://www.wholecell.org/school-2017/

Weaknesses in current work:
- The code base for the Covert lab's whole cell model is in Matlab. Would need to create a python port.
- Code is specific for M. Genitalium. Would need to create a system capable of being applied to different tumor cell lines or the like.

Start with the linked papers, wholecell.org materials, and the CovertLab/WholeCell repository to understand the existing MATLAB model and its M. genitalium-specific scope. Define whether the first milestone is a Python port, support for other cell lines, or a drug-discovery adaptation; the issue currently does not specify a bounded implementation or completion test.

Written by the indexing model from the issue text.