Create a "Panel of Normals"

# Create a "Panel of Normals"

## Aim

Read about what usually goes into a "panel of normals" (PON). Summarize what you find in a doc on the DCL overview wiki and present it to us at an SF Python Project Night.

## Background

In my mind a PON is a consensus sequence. A consensus sequence is the mode (at each nucleotide) of a number of sequences. But what sequences do you use to make the consensus?

If we had non-tumor cells from the same patient we could use those to determine the 'normal' sequence. But many cancer samples don't have a matching non-tumor sample. For these cases what should we use?

Read more starting here:
- [gatkforum](https://gatkforums.broadinstitute.org/gatk/discussion/11053/panel-of-normals-pon)
- [gatkforum mutect2](https://gatkforums.broadinstitute.org/gatk/discussion/6904/panel-of-normals-for-mutect)
- [Biostars](https://www.biostars.org/p/372159/)
- [Cosmic](https://cancer.sanger.ac.uk/cosmic/analyses)