deepcelllineage / deepcelllineage/mitolin

Annotate a-helices, b-sheets, and loops of mitochondiral protein cytochrome b

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Description

## Aim

Annotate a-helices, b-sheets, and loops of mitochondiral protein cytochrome b

## Background

Protein structural motif metadata can help make sense of nucleotide variation. Motifs include alpha-helices, beta-sheets, loops, internal and external exposed amino acids, extracellular, intracellular, and transmembrane domains.

## Method

Start by reading this [paper](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586544/).

## Data

Use sequence A07 from here:

deepcelllineage/data01/gen/nguyen_nc_2018/20190710-320lfastas/
(data01 is a repo within deepcelllineage)

A link to the files is here:
https://github.com/deepcelllineage/data01/tree/master/gen/nguyen_nc_2018/20190710-320lfastas

These are .fasta files that are the full length of the mitochondrial gene plus some of chr1. There is a separate issue to chop off the chr1 part.

## Document your learning process

Please fork & clone this repo. Check out a branch for your work, then push and make a PR for us to merge your note and files.

Add a note (can be .md or .ipynb) with your steps in [mitolin/nb](https://github.com/deepcelllineage/mitolin/tree/master/nb).

Your note should be named as follows:

- DATE-issue#-shortdescription.ext

e.g.:

- 20190701-i11-annotate-cb-abloop.md

## Questions?

Please put questions related to this issue in this issue thread.

If you want a quick response, post a link to your comment in this thread to Slack #deepcelllineage and tag @Deena or others. You can also DM @Deena.

To join Slack enter your email address [here](http://bit.ly/JoinSlackFastaiSFbay). For questions NOT specifically related to this issue, get in touch through any of the communication methods listed in [DCL's overview README](https://github.com/deepcelllineage/overview/blob/master/README.md).

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