deepcelllineage / deepcelllineage/mitolin
Annotate a-helices, b-sheets, and loops of mitochondiral protein cytochrome b
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Description
## Aim
Annotate a-helices, b-sheets, and loops of mitochondiral protein cytochrome b
## Background
Protein structural motif metadata can help make sense of nucleotide variation. Motifs include alpha-helices, beta-sheets, loops, internal and external exposed amino acids, extracellular, intracellular, and transmembrane domains.
## Method
Start by reading this [paper](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586544/).
## Data
Use sequence A07 from here:
deepcelllineage/data01/gen/nguyen_nc_2018/20190710-320lfastas/
(data01 is a repo within deepcelllineage)
A link to the files is here:
https://github.com/deepcelllineage/data01/tree/master/gen/nguyen_nc_2018/20190710-320lfastas
These are .fasta files that are the full length of the mitochondrial gene plus some of chr1. There is a separate issue to chop off the chr1 part.
## Document your learning process
Please fork & clone this repo. Check out a branch for your work, then push and make a PR for us to merge your note and files.
Add a note (can be .md or .ipynb) with your steps in [mitolin/nb](https://github.com/deepcelllineage/mitolin/tree/master/nb).
Your note should be named as follows:
- DATE-issue#-shortdescription.ext
e.g.:
- 20190701-i11-annotate-cb-abloop.md
## Questions?
Please put questions related to this issue in this issue thread.
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