Extend mapping references off either end
Open
Nobody has claimed this yet.
enhancement
- Dominant language
- Python
- Stars
- 21
- Forks
- 11
- Avg merge
- 12h 5m
- Merged PRs (30d)
- 24
Description
When we map reads to a protein-specific region, the reads drop off slightly as they get close to the outer edges. In order to get maximum coverage for the actual protein coding region, we should extend the mapping reference sequences by a few bases off either end.
Contributor guide
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First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
The issue names no files or tests. Start by locating where protein-specific mapping reference sequences are built, then verify that references extend by a few bases on both ends and that coverage near the coding-region edges improves.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- bioinformatics
- Issue type
- Feature
- Difficulty
- 4/5
- Estimated time
- 3-5 days
- Activity status
- Stale
- Clarity
- Mostly clear
- Newbie friendliness
- 35/100