cancervariants / cancervariants/variation-normalization
Normalization works on some NCBI 36 Variants
- Dominant language
- Python
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- 15
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- 2
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Description
### Describe the bug
My understanding is that the variation normalizer is restricted to support variants described on GRCh37/38, but it appears to currently support some variant types on NCBI 36 too.
### Steps to reproduce
```
{
"warnings": [],
"service_meta_": {
"name": "variation-normalizer",
"version": "0.15.0",
"response_datetime": "2025-08-07T16:22:55.444722Z",
"url": "https://github.com/cancervariants/variation-normalization"
},
"variation_query": "NC_000005.8:g.123452G>C",
"variation": {
"id": "ga4gh:VA.ZWdCwi4D4nKN9CpkDliDnPgyAJk5bEdb",
"type": "Allele",
"digest": "ZWdCwi4D4nKN9CpkDliDnPgyAJk5bEdb",
"location": {
"id": "ga4gh:SL._pFs_WVxZOf3ta0S2unYUuOdrsJom1JL",
"type": "SequenceLocation",
"digest": "_pFs_WVxZOf3ta0S2unYUuOdrsJom1JL",
"sequenceReference": {
"type": "SequenceReference",
"refgetAccession": "SQ.sphQQhTwLddZFu6ZmSQIR9k0FR4n_B5Z"
},
"start": 123451,
"end": 123452,
"sequence": "G"
},
"state": {
"type": "LiteralSequenceExpression",
"sequence": "C"
}
}
}
```
### Expected behavior
A warning message would be returned reporting that variants on NCBI 36 are not supported. The returned variant would be described on the NCBI 36 reference sequence.
### Current behavior
See steps to reproduce
### Possible reason(s)
_No response_
### Suggested fix
_No response_
### Branch, commit, and/or version
branch: staging
### Screenshots
_No response_
### Environment details
Mac M4
### Additional details
_No response_
### Contribution
None
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Assessment
This issue has not been assessed yet.