cancervariants / cancervariants/variation-normalization

Normalization works on some NCBI 36 Variants

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#628 1 comment 0 reactions 1 assignee Claimed by @korikuzma View on GitHub
bug priority:low
Dominant language
Python
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Description

### Describe the bug

My understanding is that the variation normalizer is restricted to support variants described on GRCh37/38, but it appears to currently support some variant types on NCBI 36 too.

### Steps to reproduce

```
{
"warnings": [],
"service_meta_": {
"name": "variation-normalizer",
"version": "0.15.0",
"response_datetime": "2025-08-07T16:22:55.444722Z",
"url": "https://github.com/cancervariants/variation-normalization"
},
"variation_query": "NC_000005.8:g.123452G>C",
"variation": {
"id": "ga4gh:VA.ZWdCwi4D4nKN9CpkDliDnPgyAJk5bEdb",
"type": "Allele",
"digest": "ZWdCwi4D4nKN9CpkDliDnPgyAJk5bEdb",
"location": {
"id": "ga4gh:SL._pFs_WVxZOf3ta0S2unYUuOdrsJom1JL",
"type": "SequenceLocation",
"digest": "_pFs_WVxZOf3ta0S2unYUuOdrsJom1JL",
"sequenceReference": {
"type": "SequenceReference",
"refgetAccession": "SQ.sphQQhTwLddZFu6ZmSQIR9k0FR4n_B5Z"
},
"start": 123451,
"end": 123452,
"sequence": "G"
},
"state": {
"type": "LiteralSequenceExpression",
"sequence": "C"
}
}
}
```

### Expected behavior

A warning message would be returned reporting that variants on NCBI 36 are not supported. The returned variant would be described on the NCBI 36 reference sequence.

### Current behavior

See steps to reproduce

### Possible reason(s)

_No response_

### Suggested fix

_No response_

### Branch, commit, and/or version

branch: staging

### Screenshots

_No response_

### Environment details

Mac M4

### Additional details

_No response_

### Contribution

None

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Assessment

This issue has not been assessed yet.

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