Uncaught ReferenceError: System is not defined in systemjs.config.js - Asp.net MVC5 angular2

I have created Asp.Net MVC Angular2 application which is working fine while running in visual studio2017 External Host. But when i publish this application and run through IIS. i am receiving an error as

Uncaught ReferenceError: System is not defined in
1. systemjs.config.js and
2. _Layout.cshtml

System.import('app').catch(function(err){ console.error(err); });

Below is my Bundle.config class:

public class BundleConfig
{
public static void RegisterBundles(BundleCollection bundles)
{
bundles.Add(new ScriptBundle("~/bundles/jquery").Include(
"~/Scripts/jquery-{version}.js"));

bundles.Add(new ScriptBundle("~/bundles/jqueryval").Include(
"~/Scripts/jquery.validate*"));

bundles.Add(new ScriptBundle("~/bundles/angular").Include(
"~/node_modules/core-js/client/shim.min.js",
"~/node_modules/systemjs/dist/system-polyfills.js",
"~/node_modules/zone.js/dist/zone.js",
"~/node_modules/systemjs/dist/system.src.js",
"~/node_modules/systemjs/dist/system.js",
"~/systemjs.config.js"

));
bundles.Add(new ScriptBundle("~/bundles/modernizr").Include(
"~/Scripts/modernizr-*"));

bundles.Add(new ScriptBundle("~/bundles/bootstrap").Include(
"~/Scripts/bootstrap.min.js",
"~/Scripts/respond.js"
));

bundles.Add(new StyleBundle("~/Content/css").Include(
"~/Content/bootstrap.min.css",
"~/Content/font-awesome.min.css",
"~/Content/animate.min.css",
"~/node_modules/angular2-busy/build/style/busy.css",
"~/node_modules/ng2-toastr/bundles/ng2-toastr.min.css",
"~/Content/custom.css"
));
}
}

systemjs.config.js

(function (global) {
System.config({
paths: {
'npm:': 'node_modules/'
},
map: {
'app': 'app',
'@angular/core': 'npm:@angular/core/bundles/core.umd.js',
'@angular/common': 'npm:@angular/common/bundles/common.umd.js',
'@angular/compiler': 'npm:@angular/compiler/bundles/compiler.umd.js',
'@angular/platform-browser': 'npm:@angular/platform-browser/bundles/platform-browser.umd.js',
'@angular/platform-browser-dynamic': 'npm:@angular/platform-browser-dynamic/bundles/platform-browser-dynamic.umd.js',
'@angular/http': 'npm:@angular/http/bundles/http.umd.js',
'@angular/router': 'npm:@angular/router/bundles/router.umd.js',
'@angular/forms': 'npm:@angular/forms/bundles/forms.umd.js',
'@angular/animations': 'npm:@angular/animations/bundles/animations.umd.js',
'@angular/animations/browser': 'npm:@angular/animations/bundles/animations-browser.umd.js',
'@angular/platform-browser/animations': 'npm:@angular/platform-browser/bundles/platform-browser-animations.umd.js',
'file-saver': 'npm:file-saver/',
'angular2-busy': 'npm:angular2-busy',

'ng2-smart-table': 'npm:ng2-smart-table',
'ng2-completer': 'npm:ng2-completer',
'ng2-bs3-modal': 'npm:/ng2-bs3-modal',
'lodash': 'npm:lodash',
'rxjs': 'npm:rxjs',
'angular-in-memory-web-api': 'npm:angular-in-memory-web-api/bundles/in-memory-web-api.umd.js',
'mydatepicker': 'npm:mydatepicker/bundles/mydatepicker.umd.min.js',
'ng2-toastr': 'npm:ng2-toastr',

'moment': 'npm:moment',
'ngx-pipes': 'npm:ngx-pipes/bundles/ngx-pipes.umd.min.js'

},
packages: {
app: { main: 'main.js', defaultExtension: 'js' },
rxjs: { defaultExtension: 'js' },
'ng2-bs3-modal': { main: '/bundles/ng2-bs3-modal.js', defaultExtension: 'js' },
'ng2-smart-table': { main: 'bundles/table.umd.js', defaultExtension: 'js' },
'ng2-completer': { main: 'ng2-completer.umd.js', defaultExtension: 'js' },
'lodash': { main: 'lodash.js', defaultExtension: 'js' },
'file-saver': { format: 'global', main: 'FileSaver.js', defaultExtension: 'js'},
'angular2-busy': { main: './index.js', defaultExtension: 'js' },
'moment': { main: 'moment', defaultExtension: 'js' },
'ng2-toastr': { main: '/bundles/ng2-toastr.min.js', defaultExtension: 'js' },
}
});
})(this);