VEuPathDB / VEuPathDB/ApiCommonWebsite

AI-assisted gene comments - minor tweaks list

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Dominant language
Perl
Stars
3
Forks
1
Avg merge
1d 21h
Merged PRs (30d)
6

Description

  • Consider adding to the prompt guidance: "Preserve the kind of relationship described in the source. Do not reinterpret proximity on an expression map, pathway map, network, clustering diagram, or dimensionality-reduction plot as physical genomic proximity." after AGAP001212 + https://pmc.ncbi.nlm.nih.gov/articles/PMC3341590/ made an incorrect assumption about genomic colocalization: "Conserved active site residues suggest amidase activity typical of catalytic PGRP family members; genomic co-localization with antimicrobial effector genes further supports this functional assignment computationally." - Claude was fooled by this passage from the paper: "PGRPLB lies in a region populated by other effector genes and peptides (GAM1 (AGAP008645), LYSC7, DEF1 and cecropins 1-3),"

Contributor guide

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First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Review the cited PMC3341590 passage and the AGAP001212 example to understand the incorrect genomic-colocalization inference. Locate the AI prompt guidance in the repository, add the requested distinction between visual proximity and physical genomic proximity, and verify that the example no longer leads to that assumption.

Written by the indexing model from the issue text.

Assessment

Tech stack
perl
Domain
ai
Issue type
Feature
Difficulty
3/5
Estimated time
1-2 days
Activity status
Quiet
Clarity
Mostly clear
Newbie friendliness
45/100

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