RosettaCommons / RosettaCommons/foundry
Does a high RMSD value imply an unsuccessful design?#question
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question
RFdiffusion3
- Dominant language
- Python
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Description
I try to design some protein binders, but most of RMSD of the design were high. All of it were more than 3A.How can I improve it?
I read some article. They always could screen some sample with low RMSD(less than 3A). I don' t know what mistake I made.
Contributor guide
First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
The issue provides only an image and RMSD observations; it names no file, test, or entry point. Start by reviewing the reported design inputs, RMSD calculation, and referenced articles, then establish what constitutes a successful binder and identify the specific cause before proposing a change.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- bioinformatics, machine-learning
- Issue type
- Bug
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 20/100