RosettaCommons / RosettaCommons/RFdiffusion

Installation support for Windows / WSL users (CUDA, DGL, cu117 issues)

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Dominant language
Python
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Forks
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Description

Hi,
I’ve been trying to install RFdiffusion on my Windows machine using WSL (Ubuntu), but I keep running into problems with dependencies — especially with CUDA, cuDNN, PyTorch (cu117), and DGL.

Even after following all available guides and trying different versions of these frameworks, installation either fails or the model won’t run properly due to GPU or CUDA compatibility issues.

It would be very helpful if the team (or community) could provide:

  1. A step-by-step guide for installation on Windows/WSL.

  2. Recommended CUDA and PyTorch versions that actually work under WSL.

  3. Any known limitations or workarounds for Windows users.

Since many researchers and developers use Windows as their main system, having an official installation guide or Docker image for WSL would make RFdiffusion much more accessible.

Thank you for your amazing work on this project — it’s an incredible tool, and I’d love to get it running locally!

Best regards,
Kamyar Entezari

Contributor guide

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First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by reviewing the available installation guides and the dependency setup for CUDA, cuDNN, PyTorch cu117, and DGL under Ubuntu on WSL. Document tested version combinations, known Windows/WSL limitations, and workarounds; if a Docker image is pursued, its supported setup should be explicitly defined.

Written by the indexing model from the issue text.

Assessment

Tech stack
docker, python, pytorch
Domain
devops, machine-learning, operating-systems
Issue type
Documentation
Difficulty
4/5
Estimated time
3-5 days
Activity status
Stale
Clarity
Mostly clear
Newbie friendliness
25/100

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