RosettaCommons / RosettaCommons/RFdiffusion
How to generate multiple helices instead of one long helix when extending a protein backbone with RFdiffusion？
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- Dominant language
- Python
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Description
Hello,
I’m using RFdiffusion to extend the backbone of a protein by approximately 33 amino acids. My goal is for these 33 residues to form at least two helices, but the generated structures always result in one single long helix instead.
Is there any way to guide or constrain RFdiffusion to produce multiple shorter helices rather than a continuous one?
Any suggestions (e.g., input setup) would be greatly appreciated.
Thank you!
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Research direction
No source file or test is identified. Start by reviewing RFdiffusion's documented backbone-extension inputs and constraints, then determine whether the requested multi-helix result is supported; done would be a documented setup that produces it or a clear statement of the limitation.
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Assessment
- Tech stack
- python
- Domain
- bioinformatics, machine-learning
- Issue type
- Documentation
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 25/100