RosettaCommons / RosettaCommons/RFdiffusion
Missing sidechain of target in output
Nobody has claimed this yet.
- Dominant language
- Python
- Stars
- 3.1k
- Forks
- 644
- PR merge metrics
- No merged PRs in 30d
Description
Hi community,
I am using RFdiffusion to design a binder for a target protein. After running the process, I've noticed that in the output PDB file, my target protein is only represented by its backbone (the sidechains are missing).
Is this the expected behavior?
What is the recommended workflow to visualize the final complete complex?
Thanks!
Contributor guide
No contributing guide indexed for this repository
First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
No file, test, or entry point is named. Start by reproducing the reported RFdiffusion output and inspecting the target representation in the resulting PDB; done means determining whether the missing sidechains are expected and documenting the recommended workflow for visualizing a complete complex.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- bioinformatics, machine-learning
- Issue type
- Bug
- Difficulty
- 4/5
- Estimated time
- 3-5 days
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 25/100